Protocol for the Uranium IRIS Assessment (Oral) (Preliminary Assessment Materials)
EPA announced the release of the Protocol for the Uranium IRIS Assessment (Oral) (Preliminary Assessment Materials) for a 30-day public comment period as announced in a February 14, 2024 Federal Register Notice. The deadline for comments is March 15, 2024.
Citation:
U.S. EPA. Protocol for the Uranium IRIS Assessment (Oral) (Preliminary Assessment Materials). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-24/013, 2024.
Impact/Purpose:
The IAP communicates to the public the plan for assessing each individual chemical and includes summary information on the IRIS Program’s scoping and initial problem formulation, objectives and specific aims for the assessment, and a PECO framework that outlines the evidence considered most pertinent to the assessment; and identification of key areas of scientific complexity.
Description:
In February 2024, EPA released the Protocol for the Uranium IRIS Assessment (Oral) (Preliminary Assessment Materials) for a 30-day public review and comment period. As part of developing a draft IRIS assessment, EPA presents a protocol that describes the methodology for how the assessment will be conducted, including systematic review and dose-response. These could include strategies for literature searches, criteria for study inclusion or exclusion, considerations for evaluating study methods, information management for extracting data, approaches for synthesis within and across lines of evidence, and methods for derivation of toxicity values.
URLs/Downloads:
Protocol for the Uranium IRIS Assessment (Oral) (Preliminary Assessment Materials) (PDF, 175 pp, 2497 KB, about PDF)Federal Register Notice: Feb 14, 2024
EPA-HQ-ORD-2017-0747
Literature Search References Sorted by Publication Year (Uranium)