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IRIS Toxicological Review of Trimethylbenzenes (Interagency Science Consultation Draft)
Citation:
U.S. EPA. IRIS Toxicological Review of Trimethylbenzenes (Interagency Science Consultation Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-11/012C, 2012.
Impact/Purpose:
EPA is reassessing its IRIS toxicological review of Trimethylbenzenes (1,2,3-;1,2,4-;1,3,5-). This trimethylbenzene reassessment consists of an oral reference dose (RfD), an inhalation reference concentration (RfC), an inhalation unit risk (IUR) and a cancer weight of evidence descriptor. This is the first assessment developing an RfC or IUR for this compound. This assessment is intended to provide human health data to support agency regulatory decisions.
Description:
On June 26, 2012, the draft Toxicological Review of Trimethylbenzenes and the draft charge to external peer reviewers were released for external peer review and public comment. The Toxicological Review and charge were reviewed internally by EPA and by other federal agencies and White House Offices before public release. Consistent with the May 2009 IRIS assessment development process, all written comments on IRIS assessments submitted by other federal agencies and White House Offices are made publicly available. Accordingly, interagency comments and the interagency science consultation materials provided to other agencies, including interagency review drafts of the IRIS Toxicological Review of Trimethylbenzenes and the charge to external peer reviewers, are posted on this site.
URLs/Downloads:
IRIS Toxicological Review of Trimethylbenzenes (Interagency Science Consultation Draft), Jan 2012 (PDF, 95 pp, 1066 KB, about PDF)Draft Charge to External Peer Reviewers (Interagency Science Consultation Draft) Jan 2012 (PDF, 5 pp, 45 KB, about PDF)
EPA's Response and Comments from the Interagency Science Consultation (PDF, 10 pp, 247 KB, about PDF)
1. CDC ATSDR Comments on the TMB IASC (PDF, 2 pp, 29 KB, about PDF)
2. CEQ Comments on the TMB IASC (PDF, 1 pp, 48 KB, about PDF)
3. DoD DUSD ( I&E ) Comments on the TMB IASC (PDF, 26 pp, 181 KB, about PDF)
4. NIEHS NTP Comments on the TMB IASC (PDF, 1 pp, 38 KB, about PDF)
5. NIOSH Comments on the TMB IASC (PDF, 1 pp, 24 KB, about PDF)
Dose-response Analysis of 1,2,3-Trimethylbenzene (Interagency Science Consultation Draft), May 2012 (PDF, 19 pp, 683 KB, about PDF)
Supplemental Information of 1,2,3-Trimethylbenzene (Interagency Science Consultation Draft), May 2012 (PDF, 13 pp, 720 KB, about PDF)
Draft Charge Questions for 1,2,3-Trimethylbenzene, May 2012 (PDF, 1 pp, 59 KB, about PDF)
1. CEQ Comments on 1,2,3-TMB (PDF, 1 pp, 35 KB, about PDF)
2. DOD DUSD ( I&E ) Comments on 1,2,3-TMB (PDF, 2 pp, 26 KB, about PDF)
3. NIEHS NTP Comments on 1,2,3-TMB (PDF, 1 pp, 139 KB, about PDF)