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High Throughput Transcriptomics @ USEPA (Toxicology Forum)
Martin, M. High Throughput Transcriptomics @ USEPA (Toxicology Forum). Presented at Tox Forum, Salt Lake City, UT, July 28, 2016. https://doi.org/10.23645/epacomptox.5071369
Slide presentation at the 2016 ToxForum on using High Throughput Transcriptomics at US EPA for broader coverage biological activity space and toxicological MOAs.
The ideal chemical testing approach will provide complete coverage of all relevant toxicological responses. It should be sensitive and specific It should identify the mechanism/mode-of-action (with dose-dependence). It should identify responses relevant to the species of interest. Responses should ideally be translated into tissue-, organ-, and organism-level effects. It must be economical and scalable. Using a High Throughput Transcriptomics platform within US EPA provides broader coverage of biological activity space and toxicological MOAs and helps fill the toxicological data gap.
MARTIN EPA HTTR TOXFORUM SALTLAKECITY JULY 2016.PDF (PDF,NA pp, 2201.25 KB, about PDF)
Record Details:Record Type: DOCUMENT (PRESENTATION/SLIDE)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL CENTER FOR COMPUTATIONAL TOXICOLOGY