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US-EPA CompTox Chemicals Dashboard Providing Public Access to Toxicity and Exposure Data
Citation:
Williams, A., C. Grulke, A. McEachran, G. Patlewicz, I. Shah, A. Richard, K. Dionisio, K. Isaacs, K. Phillips, K. Friedman, R. Judson, J. Dunne, AND J. Edwards. US-EPA CompTox Chemicals Dashboard Providing Public Access to Toxicity and Exposure Data. Presented at American Chemical Society Spring meeting, Orlando, FL, March 31 - April 04, 2019.
Impact/Purpose:
This presentation will provide an overview of the CompTox Chemicals Dashboard and its value to the community as an informational hub. Abstract to be presented at the Spring 2019 American Chemical Society meeting.
Description:
The U.S. Environmental Protection Agency (EPA) Computational Toxicology Program integrates advances in biology, chemistry, and computer science to help prioritize chemicals for further research based on potential human health risks. This work involves computational and data driven approaches that integrate chemistry, exposure and biological data. As an outcome of these efforts the National Center for Computational Toxicology (NCCT) has measured, assembled and delivered an enormous quantity and diversity of data for the environmental sciences including high-throughput in vitro screening data, in vivo and functional use data, exposure models and chemical databases with associated properties. The CompTox Chemicals Dashboard is a freely accessible user-friendly web application that provides access to data associated with ~770,000 chemical substances. These data include human and ecological hazard data for tens of thousands of chemicals from multiple databases and peer-reviewed publications. Experimental and predicted physicochemical properties, product and functional use information and bioassay screening data associated with the ToxCast and Tox21 high throughput screening programs are also available. The application provides batch searching capability to source data for thousands of chemicals at a time as well as real-time QSAR predictions for almost two dozen physicochemical and toxicity endpoints. This presentation will provide an overview of the CompTox Chemicals Dashboard and its value to the community as an informational hub. This abstract does not necessarily represent the views or policies of the U.S. Environmental Protection Agency.