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Accelerating the Pace of Chemical Risk Assessment (APCRA): An International Governmental Collaborative Initiative
Citation:
Gwinn, M. AND K. Friedman. Accelerating the Pace of Chemical Risk Assessment (APCRA): An International Governmental Collaborative Initiative. Presented at CSS Science Seminar Series Webinar, Washington, DC, June 25, 2019. https://doi.org/10.23645/epacomptox.8512133
Impact/Purpose:
Accelerating the Pace of Chemical Risk Assessment (APCRA) is a government-to-government initiative whose aim is to promote collaboration and dialogue on the scientific and regulatory needs for the application and acceptance of NAMs in regulatory decision making. This presentation will give an overview of the meeting discussions, as well as a high-level overview of some of the collaborative case studies designed to aid in increasing acceptance of these new alternative methods and tools in regulatory decisions.
Description:
New approach methodologies (NAMs) play a key role in accelerating the pace of chemical risk assessment and are an important tool for the future of regulatory decision making. Accelerating the Pace of Chemical Risk Assessment (APCRA) is a government-to-government initiative whose aim is to promote collaboration and dialogue on the scientific and regulatory needs for the application and acceptance of NAMs in regulatory decision making. APCRA began in 2016 with a workshop designed to bring together regulatory agencies from around the world to discuss their development and implementation of higher throughput hazard, exposure, and risk assessment methods and approaches in their chemical evaluation activities. From this start, APCRA has focused on bringing together international regulators to discuss progress and address barriers in applying new tools to prioritization, screening, and quantitative risk assessment of differing levels of complexity through increased collaboration through case studies. Criteria for collaborative case studies include the use of a NAM in a clear regulatory application and the involvement of multiple regulatory agencies. The following workshops continued these discussions and expanded the focus to include the development and implementation of exposure and ecology NAMs, in 2017 and 2018 respectively. The most recent workshop also included discussions focused on establishing confidence in the use of NAMs, both in terms of comparisons to traditional methods and integrating divergent data streams. This presentation will give an overview of the meeting discussions, as well as a high-level overview of some of the collaborative case studies designed to aid in increasing acceptance of these new alternative methods and tools in regulatory decisions. The views expressed are those of the authors and do not necessarily represent the policies of the US Environmental Protection Agency, Health Canada or European Chemicals Agency.
URLs/Downloads:
DOI: Accelerating the Pace of Chemical Risk Assessment (APCRA): An International Governmental Collaborative Initiative
GWINN_APCRA_2019_CSS_OVERVIEW_CASESTUDIES_FINAL.PDF (PDF, NA pp, 4401 KB, about PDF)