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Novel In Vitro Approach to Assess Multiple Species’ Susceptibility to Potential Endocrine Disruptors
Citation:
Simha, A., K. Houck, C. Lalone, A. Bone, R. Judson, M. Martin, D. Villeneuve, G. Ankley, A. Medvedev, AND S. Makarov. Novel In Vitro Approach to Assess Multiple Species’ Susceptibility to Potential Endocrine Disruptors. Presented at Endocrine Disruption conference at NIEHS, RTP, NC, April 05, 2019. https://doi.org/10.23645/epacomptox.8023451
Impact/Purpose:
Poster to be presented at the Endocrine Disruption conference at NIEHS in April 2019. A multiplexed, multi-receptor transactivation assay was developed to target nuclear receptors from a diverse set of ecological species. Screening a targeted library showed correlation between species’ receptor sequence similarity and chemical response.
Description:
Screening technologies have been developed to identify xenobiotic chemicals that bind nuclear receptors and thus have potential for adverse health effects through disruption of endocrine function. However, the focus has been on human receptors despite environmental exposure to a huge diversity of other species. We evaluated a multiplexed transactivation assay providing the ability to screen for effects across multiple species and nuclear receptors. This abstract does not reflect the policies of the US EPA.
URLs/Downloads:
DOI: Novel In Vitro Approach to Assess Multiple Species’ Susceptibility to Potential Endocrine Disruptors
2019_EDCNC_SIMHA_V2.PDF (PDF, NA pp, 406.848 KB, about PDF)