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High-Throughput Toxicokinetics (HTTK)
Citation:
Wambaugh, J. High-Throughput Toxicokinetics (HTTK). OECD/JRC Webinar Meeting, Durham,NC, September 27, 2018. https://doi.org/10.23645/epacomptox.7335821
Impact/Purpose:
In order to address greater numbers of chemicals we collect in vitro, high throughput toxicokinetic (HTTK) data. HTTK methods have been used by the pharmaceutical industry to determine range of efficacious doses and to prospectively evaluate success of planned clinical trials. The primary goal of HTTK is to provide a human dose context for bioactive in vitro concentrations from HTS. The secondary goal is to provide open source data and models for evaluation and use by the broader scientific community.
Description:
We are working to augment the basic HT-PBPTK (physiologically-based toxicokinetic model) with new PBTK models. Each model will be released publicly upon peer-reviewed publication. Pre-publication models can be shared under an MTA. We assume there will be coding errors and over-simplifications, so each publication involves curation of evaluation data from the scientific literature and through statistical analysis. Generic PBTK models based on HTTK seem to increase correlation between in vitro bioactivity and in vivo effects. Using PBTK to predict tissue concentrations does better than using administered dose (or PBTK for random chemical).
URLs/Downloads:
DOI: High-Throughput Toxicokinetics (HTTK)
WAMBAUGH_HTTK-OECD-092118.PDF (PDF, NA pp, 1690.007 KB, about PDF)