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Cytological Profiling for Bioactivity Screening of Chemicals
Citation:
Nyffeler, J. Cytological Profiling for Bioactivity Screening of Chemicals. Presented at Perkin Elmer User Group Meeting at Society of Biomolecular Imaging and Informatics (SBI2), Boston, MA, September 18 - 20, 2018. https://doi.org/10.23645/epacomptox.7227533
Impact/Purpose:
To explore whether phenotypic profiling is a useful screening method for hazard identification and characterization. Presentation to the Perkin Elmer User Group Meeting at Society of Biomolecular Imaging and Informatics (SBI2) meeting Sep 2018
Description:
The goal of the experimental design is to replicate data from a published study using the same cell line, chemical set, and exposure time run in concentration-response mode. Potential applications are estimation of in vitro point-of-departures (POD), and profiles could provide mechanistic insights. The EPA is evaluating the use of cytological profiling to test chemicals to find the onset of bioactivity and mechanistic information.
URLs/Downloads:
DOI: Cytological Profiling for Bioactivity Screening of Chemicals
NYFFELER_180917 PERKINELMER USERGROUP V5.PDF (PDF, NA pp, 7389.693 KB, about PDF)