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Framework for Predictive Developmental Toxicity of Chemicals Regulated under TSCA
Citation:
Knudsen, T. AND S. Hunter. Framework for Predictive Developmental Toxicity of Chemicals Regulated under TSCA. Presented at Office of Chemical Safety and Pollution Prevention (OCSPP) Visit to RTP June 2018, RTP, NC, June 08, 2018. https://doi.org/10.23645/epacomptox.6991199
Impact/Purpose:
Poster presentation to the EPA Office of Chemical Safety and Pollution Prevention (OCSPP) June 2018
Description:
Assigning chemicals under amended TSCA to low and high priority comes with uncertainties in complexity of predicting toxicity during pregnancy. A DevTox predictive framework will implement data from in vitro assays assessing embryonic cell growth and differentiation. The framework will operationalize a defined interpretation protocol for computational synthesis and integration, i.e. a DevTox decision tree. Multiscale modeling and simulation will provide tools and approaches to virtually reconstruct and analyze complexity and quantitative prediction.
URLs/Downloads:
DOI: Framework for Predictive Developmental Toxicity of Chemicals Regulated under TSCA
KNUDSEN_8.DEVTOX_06082018.PDF (PDF, NA pp, 981.97 KB, about PDF)