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Examining the Utility of In Vitro Bioactivity as a Conservative Point of Departure:A Case Study
Citation:
Paul-Friedman, K. AND R. Thomas. Examining the Utility of In Vitro Bioactivity as a Conservative Point of Departure:A Case Study. Presented at International Council of Chemical Associations Long-Range Research Initiative (ICCA-LRI) Workshop, Ottawa, n/a, CANADA, June 20 - 21, 2018. https://doi.org/10.23645/epacomptox.6991100
Impact/Purpose:
Presentation at the International Council of Chemical Associations Long-Range Research Initiative (ICCA-LRI) Workshop June 2018
Description:
A simplistic approach to using in vitro bioactivity data as a POD appears to be a conservative estimate greater than 90% of the time for 448 chemicals. When combined with high-throughput exposure estimates, this approach provides a reasonable basis for risk-based prioritization and screening level risk assessments. Specific types of chemicals may be currently outside the domain of applicability due to assay limitations, e.g., organophosphate insecticides: how do we identify these in the future? Additional research to include expanded and improved high-throughput toxicokinetics and in vitro disposition kinetics may help improve POD-NAM estimates.
URLs/Downloads:
DOI: Examining the Utility of In Vitro Bioactivity as a Conservative Point of Departure:A Case Study
PAULFRIEDMAN_APCRA_4ICCALRI_JUN18.PDF (PDF, NA pp, 1423.515 KB, about PDF)