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Examining the Utility of In Vitro Bioactivity as a Conservative Point of Departure: A Case Study
Citation:
Paul-Friedman, K. AND R. Thomas. Examining the Utility of In Vitro Bioactivity as a Conservative Point of Departure: A Case Study . Presented at RIVM Netherlands National Institute for Public Health and the Environment EPA Visit, RTP, NC, April 18, 2018. https://doi.org/10.23645/epacomptox.6879635
Impact/Purpose:
Presentation at RIVM (Netherlands National Institute for Public Health and the Environment) visit to EPA on April 18, 2018
Description:
This gives an overview of an international case study on advancing the pace of chemical risk assessment (APCRA) that asks if in vitro bioactivity can be used to derive a conservative point-of-departure (POD) for prioritization and screening level risk assessment. When combined with high-throughput exposure estimates, this approach provides a reasonable basis for risk-based prioritization and screening level risk assessments. Additional research to include expanded and improved high-throughput toxicokinetics and in vitro disposition kinetics may help improve POD estimates.
URLs/Downloads:
DOI: Examining the Utility of In Vitro Bioactivity as a Conservative Point of Departure: A Case Study
PAULFRIEDMAN_SOT_2018_APCRA_CASESTUDY_V2_CHEMCENSORED.PDF (PDF, NA pp, 1912.864 KB, about PDF)