Science Inventory

ToxCast Data Expands Universe of Chemical-Gene Interactions (SOT)

Citation:

Watford, S. ToxCast Data Expands Universe of Chemical-Gene Interactions (SOT). Presented at SOT Annual Meeting, Baltimore, MD, March 12 - 16, 2017.

Impact/Purpose:

Slide or platform presentation at the 2017 SOT annual meeting. The ToxCast chemical screening program has produced bioactivity data for nearly 2000 chemicals and over 450 gene targets. This work aims to evaluate the information gained from the ToxCast project by integrating ToxCast data with chemical-gene interactions mined from literature.

Description:

Characterizing the effects of chemicals in biological systems is often summarized by chemical-gene interactions, which have sparse coverage in literature. The ToxCast chemical screening program has produced bioactivity data for nearly 2000 chemicals and over 450 gene targets. This work aims to evaluate the information gained from the ToxCast project by integrating ToxCast data with chemical-gene interactions mined from literature. Using novel approaches in information retrieval, the findings show ToxCast provides a significant amount of chemical bioactivities not found in literature. These findings implicate gaps in knowledge about chemical effects on biological systems and provide insight into further big data integration for knowledge discovery. This abstract does not necessarily represent U.S. EPA policy

URLs/Downloads:

WATFORD_SOT2017_SESSION_ABSTRACT.PDF   (PDF,NA pp, 37.395 KB,  about PDF)

WATFORD_SOT2017_PRESENTATION_FINAL.PDF   (PDF,NA pp, 724.073 KB,  about PDF)

Record Details:

Record Type: DOCUMENT (PRESENTATION/SLIDE)
Product Published Date: 03/16/2017
Record Last Revised: 03/12/2018
OMB Category: Other
Record ID: 339870

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL CENTER FOR COMPUTATIONAL TOXICOLOGY