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Systems Toxicology of Embryo Development (9th Copenhagen Workshop)
Knudsen, T. Systems Toxicology of Embryo Development (9th Copenhagen Workshop). Presented at 9th Copenhagen Workshop (COW), Copenhagan, DENMARK, May 02 - 05, 2017.
Presentation at the Copenhagen workshop on Systems Toxicology of Embryo Development.
An important consideration for predictive toxicology is to identify developmental hazards utilizing mechanism-based in vitro assays (e.g., ToxCast) and in silico multiscale models. Steady progress has been made with agent-based models that recapitulate morphogenetic drivers for angiogenesis, somitogenesis, urethrogenesis, and palatogenesis. Additional models are underway for the neurovascular unit, endocardial cushions, and neural tube closure. Individually, these models can simulate emergent phenotypes and predict adverse outcomes or ‘cybermorphs’ to essentially bring an AOP to life utilizing computational dynamics. Collectively, their compilation into an integrated array or ‘virtual embryo’ motivates the construction of novel ontology systems to integrate molecular pathways, cellular behaviors, and in vitro data on chemical-biological interactions with extant knowledge of embryology. This abstract does not reflect US EPA policy.
URLs/Downloads:COW_KNUDSEN_2017_FINAL_M.PDF (PDF,NA pp, 4539.852 KB, about PDF)
COW_KNUDSEN_SPEAKER_ABSTRACT.PDF (PDF,NA pp, 100.174 KB, about PDF)
Record Details:Record Type: DOCUMENT (PRESENTATION/SLIDE)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL CENTER FOR COMPUTATIONAL TOXICOLOGY