Citation:

Juberg, D., T. Knudsen, M. Sander, N. Beck, E. Faustman, D. Mendrick, J. Fowle, T. Hartung, R. Tice, E. Lamazurier, R. Becker, S. Fitzpatrick, G. Daston, A. Harill, R. Hines, D. Keller, J. Lipscomb, D. Watson, T. Bahadori, AND K. Crofton. FutureTox III: Bridges for Translation. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 155(1):22-31, (2017).

Impact/Purpose:

• Agency Research Drivers - U.S. EPA Program and Regional Offices are often tasked with addressing the potential hazard(s) of chemicals for which little-to-no data exist. • Science Challenge – One approach to estimate toxicity of thousands of chemicals for application in Agency risk decisions is using high throughput approaches. These high throughput assays examine how chemical cause toxicity on a molecular or cellular level. How to use these 21st century approaches to inform regulatory decisions is still unclear. • Research Approach – A workshop, entitled FutureTox III, was held to discuss the state of the science in toxicology and human risk and exposure assessment. • Results – At this workshop, ~300 participants reviewed and discussed moving the high throughput approaches into the arena of regulatory decision-making. The present document describes key discussion points and outcomes of a Society of Toxicology (SOT) Contemporary Concepts in Toxicology (CCT) Workshop. • Anticipated Impact/Expected use – This report lays to groundwork for bridging the gap between high throughput approaches and Agency regulatory decisions.

Description:

The present document describes key discussion points and outcomes of a Society of Toxicology (SOT) Contemporary Concepts in Toxicology (CCT) Workshop, entitled FutureTox III1,2 that was held in Crystal City, Virginia, November 19-20, 2015. The workshop built on the many lessons learned from the first 10 years of TT21 and the first two workshops in the FutureTox series (for summary of FutureTox II see (Knudsen et al., 2015); for summary of FutureTox I see (Rowlands et al., 2014)). FutureTox III was attended in person and via webcast by more than 300 scientists from government research and regulatory agencies, research institutes, academia, and the chemical and pharmaceutical industries in Europe, Canada, and the United States. The meeting materials for FutureTox III, currently available to meeting registrants at http://www.toxicology.org/events/shm/cct/meetings.asp#upcoming-pnl-open, will be open to the public on November 29, 2016. At this workshop, participants reviewed and discussed the state of the science in toxicology and human risk and exposure assessment with a focus on moving TT21 science into the arena of regulatory decision-making.

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