Science Inventory

The Human Toxome Project

Citation:

Bouhifd, M., M. Andersen, C. Baghdikian, K. Boekelheide, K. Crofton, A. Fornace Jr., A. Kleensang, H. Li, C. Livi, A. Maertens, P. McMullen, M. Rosenberg, R. Thomas, M. Vantangoli, J. Yager, L. Zhao, AND T. Hartung. The Human Toxome Project. ALTEX. Society ALTEX Edition, Kuesnacht, Switzerland, 32:112-124, (2015).

Impact/Purpose:

A reasonably comprehensive public database of PoT, the Human Toxome Knowledge--‐base, could become a point of reference for toxicological research and regulatory tests strategies.

Description:

The Human Toxome project, funded as an NIH Transformative Research grant 2011--‐ 2016, is focused on developing the concepts and the means for deducing, validating, and sharing molecular Pathways of Toxicity (PoT). Using the test case of estrogenic endocrine disruption, the responses of MCF--‐7 human breast cancer cells are being phenotyped by transcriptomics and mass--‐spectroscopy--‐based metabolomics. The bioinformatics tools for PoT deduction represent a core deliverable. A number of challenges for quality and standardization of cell systems, omics technologies, and bioinformatics are being addressed. In parallel, concepts for annotation, validation, and sharing of PoT information, as well as their link to adverse outcomes, are being developed. A reasonably comprehensive public database of PoT, the Human Toxome Knowledge--‐base, could become a point of reference for toxicological research and regulatory tests strategies.

URLs/Downloads:

http://altweb.jhsph.edu/altex/32_2/Bouhifd.pdf   Exit

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Product Published Date: 03/04/2015
Record Last Revised: 09/25/2015
OMB Category: Other
Record ID: 309453

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL CENTER FOR COMPUTATIONAL TOXICOLOGY