Science Inventory

Predicting Lactational and Early Post-Weaning Exposures in Rats Using Biologically Based Pharmacokinetic Modeling

Citation:

Yoon, M. AND H. A. BARTON. Predicting Lactational and Early Post-Weaning Exposures in Rats Using Biologically Based Pharmacokinetic Modeling. Presented at Society of Toxicology, Seattle, WA, March 16 - 20, 2008.

Impact/Purpose:

The model predictions can be used to help design early life toxicity and pharmacokinetic studies and better interpret study findings, leading to improved risk assessments.

Description:

Risk and safety assessments for early life exposures to environmental chemicals or pharmaceuticals based on cross-species extrapolation would greatly benefit from information on chemical dosimetry in the young.

URLs/Downloads:

MYOON-SOT-2008_FINAL.PDF  (PDF, NA pp,  319  KB,  about PDF)

MYOON-SOT2008 ABS.PDF  (PDF, NA pp,  50  KB,  about PDF)

Record Details:

Record Type:DOCUMENT( PRESENTATION/ POSTER)
Product Published Date:03/17/2008
Record Last Revised:12/04/2008
OMB Category:Other
Record ID: 191005