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PROMOTING DATA STANDARDS AND OPEN PUBLIC ACCESS TO STRUCTURE-SEARCHABLE TOXICITY DATABASES: DSSTOX AND COORDINATED PUBLIC EFFORTS
RICHARD, A. M. AND M. A. WOLF. PROMOTING DATA STANDARDS AND OPEN PUBLIC ACCESS TO STRUCTURE-SEARCHABLE TOXICITY DATABASES: DSSTOX AND COORDINATED PUBLIC EFFORTS. Presented at American Chemistry Society National Fall Mtg, Washington, DC, August 31 - September 03, 2005.
The Distributed Structure-Searchable Toxicity (DSSTox) database project seeks to: promote use of chemical structure standards and file formats for chemical toxicity databases; coordinate with other public efforts to encourage chemical structure annotation, data standardization, and open public access to toxicity databases; and enhance the ability of scientists and regulators within and outside EPA to integrate, explore, and utilize chemical toxicity data from a structural perspective to improve capabilities in predictive toxicology. DSSTox is coordinating with the public LIST ToxML and International Life Sciences Institute on toxicity data standardization efforts in Developmental Toxicity and other areas of toxicology. Additional collaborations are ongoing with the LHASA VITIC structure-activity database effort, the National Cancer Institute’s chemical databases and structure-browser, NCBI’s PubChem, the IUPAC/NIST InChI chemical information code project, and the NIEHS Chemical Effects in Biological Systems (CEBS) toxicogenomics knowledge-base, among others.
An explanation of what the Distributed Structure-Searchable Toxicity (DSSTox) database project is trying to accomplish.