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Use of a Defined Approach for Identifying Estrogen Receptor Active Chemicals
Citation:
Gwinn, M. Use of a Defined Approach for Identifying Estrogen Receptor Active Chemicals. Presented at International Symposium on Chemicals Risk Prediction and Management (ISCRPM), Dalian, N/A, CHINA, April 24 - 25, 2018. https://doi.org/10.23645/epacomptox.6879437
Impact/Purpose:
Presentation at the International Symposium on Chemicals Risk Prediction and Management (ISCRPM) April 2018
Description:
The advantage of applying a defined approach (DA) to inform a widespread issue like endocrine disruption is that DAs are fixed approaches that do not rely on expert judgement, so yield predictable results. As such, these may then be developed into OECD test guidelines as part of the mutual acceptance of data (MAD) system. Further, the results of this DA may be incorporated into an integrated approach to testing and assessment (IATA) for future decision-making. We present a performance-based approach to validate computational toxicology tools for evaluating a chemical’s potential ER agonist bioactivity and as alternative data for existing EDSP Tier 1 in vitro and in vivo assays.
URLs/Downloads:
DOI: Use of a Defined Approach for Identifying Estrogen Receptor Active Chemicals
GWINN-ER PATHWAY MODEL-DUT2018V3.PDF (PDF, NA pp, 1675.72 KB, about PDF)