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Physiologically Based Pharmacokinetic Models and Applications in Chemical Risk Assessments - Haverford College Invited Presentation
Citation:
Kapraun, D. Physiologically Based Pharmacokinetic Models and Applications in Chemical Risk Assessments - Haverford College Invited Presentation. Math 382: Mathematical Modeling and Differential Equations (Guest Lecture), Haverford, PA, October 04, 2023.
Impact/Purpose:
This Sub-Product includes materials (presentation slides) for an invited presentation at Haverford College on 10/4/2023. This presentation will include a description of the fundamental concepts underlying PBPK modeling and a discussion of applications of PBPK models in human health chemical risk assessments such as those conducted by the Integrated Risk Information System (IRIS) Program of the U.S. Environmental Protection Agency.
Description:
Topics for this presentation: Chemical (human health) risk assessment Dose-response analysis Pharmacokinetic (PK) and physiologically based pharmacokinetic (PBPK) models Dose metrics Dosimetry and dose extrapolation with PBPK models