Integrated Science Assessment (ISA) for Lead (Final Report)
Citation:
U.S. EPA. Integrated Science Assessment (ISA) for Lead (Final Report). U.S. Environmental Protection Agency, Washington, DC, EPA/600/R‑23/375, 2024.
Impact/Purpose:
Lead is one of six principal (or “criteria”) pollutants for which EPA has established NAAQS. EPA periodically reviews the scientific basis for these standards by preparing an ISA. The external review draft of the Pb ISA was reviewed by the Clean Air Scientific Advisory Committee (CASAC), an independent science advisory committee mandated by Section 109 (d) (2) of the Clean Air Act (CAA). The 2024 final Pb ISA represents the Agency’s latest evaluation of the scientific literature on relationships between air-related Pb exposure and health and welfare effects.
Description:
EPA announced the availability of the final report, Integrated Science Assessment ISA for Lead Pb. This document represents a concise synthesis and evaluation of the most policy-relevant science and will provide the scientific basis for EPA’s review of the National Ambient Air Quality Standards (NAAQS) for Pb.
URLs/Downloads:
Integrated Science Assessment for Lead (EPA/600/R-23/375) (PDF, 155 pp, 4239 KB, about PDF)Appendix 1. Source to Concentration (PDF, 102 pp, 2421 KB, about PDF)
Appendix 2. Exposure, Toxicokinetics, and Biomarkers (PDF, 168 pp, 2527 KB, about PDF)
Appendix 3. Nervous System Effects (PDF, 551 pp, 5965 KB, about PDF)
Appendix 4. Cardiovascular Effects (PDF, 172 pp, 3331 KB, about PDF)
Appendix 5. Renal Effects (PDF, 89 pp, 1782 KB, about PDF)
Appendix 6. Immune Effects (PDF, 91 pp, 1531 KB, about PDF)
Appendix 7. Hematological Effects (PDF, 44 pp, 1252 KB, about PDF)
Appendix 8. Reproductive and Developmental Effects (PDF, 268 pp, 2596 KB, about PDF)
Appendix 9. Effects on Other Organ Systems and Mortality (PDF, 168 pp, 2057 KB, about PDF)
Appendix 10. Cancer (PDF, 54 pp, 1000 KB, about PDF)
Appendix 11. Ecological Effects (PDF, 249 pp, 4989 KB, about PDF)
Appendix 12. ISA Process (PDF, 43 pp, 1075 KB, about PDF)
HERO: Literature Search References Sorted By Date for Lead (Pb) (2024)
HAWC: ORD - Integrated Science Assessment for Lead (Pb ISA) (2024)
FR Notice: Feb 7, 2024
