Citation:

OShaughnessy, K., F. Fischer, AND A. Zenclussen. Perinatal exposure to endocrine disrupting chemicals and neurodevelopment: how articles of daily use influence the development of our children. Best Practice & Research Clinical Endocrinology & Metabolism. Elsevier B.V., Amsterdam, Netherlands, 35(5):101568, (2021). https://doi.org/10.1016/j.beem.2021.101568

Impact/Purpose:

It is well accepted that the endocrine and immune systems interact, as nearly every immune cell in the body expresses hormone receptors. However, it is not understood if environmental endocrine disrupting chemicals (EDCs) may also affect the immune system in humans. In addition, as neurodevelopmental disorders often co-manifest with immune dysfunction in affected children, there likely exists a complex interplay between the endocrine system, immunomodulation, and brain development. In this invited review we describe how three classes of EDCs (phthalates, perfluoroalkyl substances, and bisphenols) are associated with both immune dysfunction and developmental neurotoxicity in both humans and experimental models (i.e.: rats, mice, and cell culture). Our findings suggest that certain chemicals are associated with both immunotoxicity and abnormal brain development and function, though in the future additional studies are needed to fully describe mechanisms of toxicity.  

Description:

Substances that interfere with the body’s hormonal balance or their function are called endocrine disrupting chemicals (EDCs). Many EDCs are ubiquitous in the environment and are an unavoidable aspect of daily life, including during early embryogenesis due to placental transfer. Developmental exposure to these chemicals is of critical relevance, as EDCs can permanently alter developmental programs, including those that pattern and wire the brain. Of emerging interest is how these chemicals may also affect the immune response, given the cross-talk between the endocrine and immune systems. As brain development is strongly dependent on hormones including thyroid, androgens, and estrogens, and can also be affected by immunomodulation, this complicated interplay may have long-lasting neurodevelopmental consequences. This review focuses on data available from human cohorts, in vivo models, and in vitro assays regarding the impact of EDCs after a gestational and/or lactational exposure, and how they may impact the immune system and/or neurodevelopment. We aim to contribute to the better understanding of EDC impact on both immunomodulation and neurodevelopment and recommend strategies to reduce exposure.

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