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Introduction to EPA’s human health risk assessment practices for chemical mixtures
Citation:
Rice, G. Introduction to EPA’s human health risk assessment practices for chemical mixtures. Mixtures Modeling Methods: Applications for Assessing Polychlorinated Biphenyls (PCBs), NA, DC, March 16, 2022.
Impact/Purpose:
This power point file supports the first talk in a Public Webinar being held Integrated Risk Information System (IRIS) Program. The webinar is titled "Mixtures Modeling Methods: Applications for Assessing Polychlorinated Biphenyls (PCBs)". There are three additional talks in the Webinar.
Description:
This talk broadly overviews human health risk assessment practices used to evaluate risks and hazards associated with chemical mixtures in the environment. Following a brief introduction, the talk addresses component methods used by EPA, methods used to evaluate human health risks and health hazards associated with whole mixtures, and approaches that have been developed to evaluate sufficient similarity among mixtures. In its Supplementary Mixtures Guidance, EPA offered that, when toxicity data for a specific mixture are not available for use in risk assessment, health risk values from a mixture judged to be sufficiently similar could be used as a surrogate.