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Two Talks supporting the Workshop: Chemical Mixtures Health Risk Assessment of Environmental Contaminants: Concepts, Methods, Applications and Advanced Topics. (Talk 1) Introduction and (Talk 8) Evaluating Risks Based on Whole Chemical Mixtures Information
Citation:
Rice, G. Two Talks supporting the Workshop: Chemical Mixtures Health Risk Assessment of Environmental Contaminants: Concepts, Methods, Applications and Advanced Topics. (Talk 1) Introduction and (Talk 8) Evaluating Risks Based on Whole Chemical Mixtures Information. Society of Risk Analysis Annual Meeting, NA, December 05 - 10, 2021.
Impact/Purpose:
These two presentations will support a workshop held at the Society of Risk Analysis Annual Meeting. The workshop will present methods to evaluate health risks posed by chemcial mixtures.
Description:
This full-day workshop focuses on current and emerging methods and data for assessing health risks posed by exposures to chemical mixtures in the environment. Key concepts and terminology are presented, and both whole mixture and component-based methods are discussed. Response addition and dose addition are described and include the following methods: the hazard index (HI), interaction-based HI, relative potency factors, toxicity equivalence factors, integrated addition, and detection of departures from dose addition. Whole mixture methods consist of the derivation of toxicity values for whole mixtures, sufficient similarity and mixture fractions. Future directions are discussed, including the use of data from new alternative methods (NAM) to inform chemical mixture risk assessment methods, a toxicology study design for verifying methods, and kinetics/metabolism of mixtures. The risk assessment examples developed in the workshop are adapted from real-world mixture analyses, e.g., waste site contaminants, pesticide applications, botanical ingredients and drinking water disinfection by-product exposures. The “hands-on” exercise, demonstrating the methods is an essential part of this workshop. Discussions include real world examples, exercise results, and answers to general questions. (We ask participants to bring a calculator or laptop). The views expressed in this abstract are those of the authors and do not necessarily reflect the views or policies of the USEPA.