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BMDS Version 3.3 User Guide (Oct 2022)
Citation:
U.S. EPA. BMDS Version 3.3 User Guide (Oct 2022). U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-21/245, 2022.
Impact/Purpose:
The U.S. Environmental Protection Agency (EPA) Benchmark Dose Software (BMDS) was developed as a tool to facilitate the application of benchmark dose (BMD) methods to EPA hazardous pollutant risk assessments.
Description:
The BMDS 3.3 User Guide is a thorough revision of the 3.2 User Guide. The guide’s technical and conceptual explanations were comprehensively updated to reflect the latest changes to the underlying model code. The User Guide also includes screenshots and procedures for BMDS Online, which was co-released with the BMDS 3.3 Excel product.
BMDS v3.3 and BMDS Online are applications to facilitate dose-response modeling. BMDS models are accessible via an Excel-based user interface using the latest update of BMDS v3.3 (downloadable) or online via the BMDS Online module. Dose-response modeling is a technique, often used in toxicology and risk assessment, for quantitatively relating exposure (the dose) to a biological outcome (the response). It may be thought of as an elaborate form of regression, which is the statistical technique used to explore or represent the relationship(s) between two (or more) variables. In the dose-response context, the dose term (e.g., mg of chemical per kg body weight per day) is most often viewed as the “cause” of the response (e.g., presence of a tumor or other manifestation of disease or a measure of the weight of some organ that might be susceptible to the toxic effects of the exposure).
The BMDS v3.3 User Guide is a companion document to both the BMDS 3.3 Excel and BMDS Online applications, and provides users with procedural “how-to” information on using either tool to create benchmark dose analyses, generate results, and produce reports. The User Guide also provides detailed explanations of each of the models used for dose-response analysis. This information may be critical to a risk assessor seeking to understand how a specific dose-response analysis result was calculated.
URLs/Downloads:
BMDS 3.3 User Guide (October 2022) (PDF, 134 pp, 5376 KB, about PDF)Download BMDS v3.3
BMDS Online
Benchmark Dose Tools home page