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The Road to Quantification of Adverse Outcome Pathways
Citation:
Druwe, I. AND X. Arzuaga. The Road to Quantification of Adverse Outcome Pathways. Society of Risk Analysis, San Antonio, TX, December 13 - 17, 2020.
Impact/Purpose:
The abstract is for a symposia on the methodologies currently being used and developed for the quantification of AOPs in chemical risk assessment along with challenges and limitations.
Description:
Adverse Outcome Pathways (AOPs) have become functional and versatile tools for use in the risk assessment work-flow. For example, mode of action information for an environmental chemical of interest may be overlaid unto an AOP to aid risk assessors in organizing the available data for a particular health hazard and identifying data gaps within pathways that lead to adverse outcomes of regulatory interest. More than qualitative tools, AOPs may become more informative as efficient tools for hazard risk assessments when they are informed with quantitative information to better inform dose response decisions. To this end a number of methodologies have been developed to try to quantify AOP such as: empirical dose-response modeling, Bayesian networks, and systems biology modeling approaches. This symposium will highlight the application of the diverse quantification methods that are being applied to AOPs. The presentations will describe AOP quantification methodologies and their application while addressing limitations and identifying future directions to use in chemical risk assessment. Disclaimer: The views expressed in this abstract are those of the authors and do not necessarily represent the views or policies of the U.S. Environmental Protection Agency.