Citation:

Alvarez-Gonzalex, M., E. Sanchez-Islas, S. Mucio-Ramirez, P. Gortari, M. Amaya, M. Leon-Olea, AND P. Kodavanti. Perinatal exposure to octabromodiphenyl ether mixture, DE-79, alters the vasopressinergic system in adult rats. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, 391(114914):1, (2020). https://doi.org/10.1016/j.taap.2020.114914

Impact/Purpose:

DE-79 belongs to Brominated Flame Retardant family of chemicals and is a commercial octa-brominated diphenyl ether mixture used in several consumer products such as computer casings. There is a great human health concern related to exposure to these compounds. Current study investigated the perinatal exposure of DE-79 on osmoregulation in adult offsprings at 3 months age. The results indicated that DE-79 disrupt vasopressinergic system (both vasopressin content and mRNA expression) by inhibiting nitric oxide production suggesting that DE-79 also has neuroendocrine effects. This information could be used by the program office in assessing the adverse effects associated with exposure to these chemicals.

Description:

Polybrominated diphenyl ethers (PBDEs) are persistent environmental pollutants considered as neurotoxicants and endocrine disruptors with important biological effects ranging from alterations in growth, reproduction, and effects on the hypothalamus-pituitary-adrenal axis. The vasopressinergic (AVPergic) system is a known target for pentaBDEs mixture (DE-71) and the structurally similar chemicals, polychlorinated biphenyls. However, the potential adverse effects of mixtures containing octaBDE compounds, like DE-79, on the AVPergic system are still unknown. The present study aims to examine the effects of perinatal DE-79 exposure on the AVPergic system. Dams were dosed from gestational day 6 to postnatal day 21 at doses of 0 (control), 1.7 (low) or 10.2 (high) mg/kg/day, and male offspring from all doses at 3-months-old were subjected to normosmotic and hyperosmotic challenge. Male offspring where later assessed for alterations in osmoregulation (i.e. serum osmolality and systemic vasopressin release), and both vasopressin immunoreactivity (AVP-IR) and gene expression in the hypothalamic paraventricular and supraoptic nuclei. Additionally, to elucidate a possible mechanism for the effects of DE-79 on the AVPergic system, both neuronal nitric oxide synthase immunoreactivity (nNOS-IR) and mRNA expression were investigated in the same hypothalamic nuclei. The results showed that perinatal DE-79 exposure AVP-IR, mRNA expression and systemic release in adulthood under normosmotic conditions and more evidently under hyperosmotic stimulation. nNOS-IR and mRNA expression were also affected in the same nuclei. Since NO is an AVP regulator, we propose that disturbances in NO could be a mechanism underlying the AVPergic system disruption following perinatal DE-79 exposure leading to osmoregulation deficits.

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