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IRIS Toxicological Review of Inorganic Arsenic (Public Comment and External Review Draft)
[UPDATE] In Dec 2023, EPA released BMD Model Code and BMD Modeling Results provided for the draft IRIS Toxicological Review of Inorganic Arsenic. This was announced in the Federal Register for a 15-day public comment and review period. [Federal Register Notice Dec 29, 2023]
Citation:
U.S. EPA. IRIS Toxicological Review of Inorganic Arsenic (Public Comment and External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-23/166, 2023.
Impact/Purpose:
EPA is developing an Integrated Risk Information System (IRIS) health assessment of Inorganic Arsenic. EPA’s draft IRIS Inorganic Arsenic assessment includes a hazard identification analysis, which summarizes the chemical properties, toxicokinetics, and health effects associated with exposure, and dose-response analysis, which characterizes the quantitative relationship between chemical exposure and each credible health hazard. These quantitative relationships are then used to derive cancer and noncancer toxicity values (e.g., inhalation unit risk, reference concentration). Once finalized, the outcome of this project will be an IRIS Toxicological Review of Inorganic Arsenic that will be entered into the IRIS database and may be used to support decisions to protect human health and the environment.
Description:
In October 2023, the IRIS Program released the draft IRIS Toxicological Review of Inorganic Arsenic for public comment and external peer review. The IRIS assessment of inorganic arsenic will undergo an independent external scientific peer review managed by EPA’s Science Advisory Board (SAB). Additional information about the peer review meeting can be found on the SAB website.
URLs/Downloads:
IRIS Toxicological Review of Inorganic Arsenic (Public Comment and External Review Draft) (PDF, 264 pp, 14345 KB, about PDF)IRIS Toxicological Review of Inorganic Arsenic (Public Comment and External Review Draft) Supplemental Information (PDF, 315 pp, 8062 KB, about PDF)
Primary Literature Search References Sorted By Author (Inorganic Arsenic)
EPA-HQ-ORD-2012-0830
FR Notice: Dec 29, 2023
FR Notice: Oct 16, 2023
Peer Review Plan (PDF, NA pp, 37 KB, about PDF)
Dose-response model code and results
Final Charge Questions for External Reviewers (Jan.) (PDF, 6 pp, 194 KB, about PDF)
REVIEW OF EPA’S DRAFT IRIS TOXICOLOGICAL REVIEW OF INORGANIC ARSENIC (PDF, 83 pp, 1462000 KB, about PDF)
IRIS TOXICOLOGICAL REVIEW OF INORGANIC ARSENIC (FINAL REPORT, 2025) (PDF, 318 pp, 178000 KB, about PDF)