Enriched housing differentially alters allostatic load and cardiopulmonary responses to wildfire-related smoke in male and female mice.
Citation:
Fiamingo, M., A. Bailey, S. Toler, K. Lee, W. Oshiro, B. Yoo, Q. Krantz, P. Evansky, D. Davies, Matthew Gilmour, A. Farraj, I. Jaspers, AND M. Hazari. Enriched housing differentially alters allostatic load and cardiopulmonary responses to wildfire-related smoke in male and female mice. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH - PART A: CURRENT ISSUES. Taylor & Francis, Inc., Philadelphia, PA, 187(14):561-578, (2024). https://doi.org/10.1080/15287394.2024.2346582
Impact/Purpose:
The purpose of this work was to examine the role of living conditions on cardiopulmonary health in mice and determine how it modifies the response to wildfire smoke. This work provides a novel mechanistic view of allostatic load and shows that enriched housing can protect from the deleterious effects of smoke.
Description:
Living conditions are an important modifier of individual health outcomes and may lead to higher allostatic load (AL). However, housing-induced cardiovascular and immune effects contributing to altered environmental responsiveness remain understudied. This investigation was conducted to examine the influence of enriched (EH) versus depleted housing (DH) conditions on cardiopulmonary functions, systemic immune responses, and allostatic load in response to a single wildfire smoke (WS) exposure in mice. Male and female C57BL/6J mice were divided into EH or DH for 22 weeks, and cardiopulmonary assessments measured before and after exposures to either one-hr filtered air (FA) or flaming eucalyptus WS exposure. Male and female DH mice exhibited increased heart rate (HR) and left ventricular mass (LVM), as well as reduced stroke volume and end diastolic volume (EDV) one week following exposure to WS. Female DH mice displayed significantly elevated levels of IL-2, IL-17, corticosterone and hemoglobin A1c (HbA1c) following WS, while female in EH mice higher epinephrine levels were detected. Female mice exhibited higher AL than males with DH, which was potentiated post-WS exposure. Thus, DH increased susceptibility to extreme air pollution in a gender-dependent manner suggesting that living conditions need to be evaluated as a modifier of toxicological responses.
URLs/Downloads:
DOI: Enriched housing differentially alters allostatic load and cardiopulmonary responses to wildfire-related smoke in male and female mice.