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The Role of HRMS in Searching for Xenobiotic Compounds in Environmental Media (2021 NEMC)
Citation:
Strynar, M. The Role of HRMS in Searching for Xenobiotic Compounds in Environmental Media (2021 NEMC). 2021 National Environmental Monitoring Conference (NEMC), Virtual, August 02 - 05, 2021.
Impact/Purpose:
High resolution mass spectrometry (HRMS) fills a critical role in environmental compound analysis and discovery. Targeted methods, while robust and needed, are not all inclusive. Non-targeted and suspect screening methods with HRMS allow for chemical screening and discovery. They should be used to inform targeted analysis methods and additional scientific investigations. The importance of HRMS analysis as a powerful supplement to robust, validated analytical methods is vital. Application of HRMS analysis to a variety of environmental samples and the resulting findings will be shown to demonstra
Description:
Mass spectrometry is at the core of understanding xenobiotic compounds in environmental media. Robust, validated methods that have been developed and used over many years help to ensure that monitoring of chemicals in the environment continue. These methods have a suite of analytes that have been included for analysis and are often called “targeted” methods as they target those analytes. While these methods perform very well for their intended purpose and must continue, there is a deficiency in this approach. Only the chemicals monitored for using these techniques can be measured. Enter the role of high-resolution mass spectrometry (HRMS) to fill this gap. Due to the intrinsic characteristic of HRMS instruments in high resolving power and exceptional mass accuracy novel xenobiotic compounds can be discovered in environmental media on a regular basis. HRMS instruments can be used to perform suspect screening analysis (looking for chemicals in a database) or true non-targeted analysis (looking for chemicals that are not in databases). As the world of chemical manufacture and creation grows at a rapid pace, so must analytical approaches to keep up with this pace in environmental monitoring. HRMS analysis should not replace targeted analysis methods, rather inform the growth of new methods and suites of analytes to consider for future targeted methods. This talk will focus on the critical role HRMS played in the discovery and monitoring of novel xenobiotic compounds in various industrially impacted settings.
