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Effects of Arsenic (As)- Contaminated Soil Exposure on Gut Bacteria and Its Relationship with Oral Bioaccessibility Using a Multi-Compartment In Vitro Gastrointestinal Modelontaminated Soil Exposure on Gut Bacteria and Its Relationship with Oral Bioaccessibility Using a Multi-Compartment In Vitro Gastrointestinal Model
Citation:
Griggs, J., D. Thomas, K. Lu, L. Chi, M. Kohan, N. Hanley, K. Herbin-Davis, AND K. Bradham. Effects of Arsenic (As)- Contaminated Soil Exposure on Gut Bacteria and Its Relationship with Oral Bioaccessibility Using a Multi-Compartment In Vitro Gastrointestinal Modelontaminated Soil Exposure on Gut Bacteria and Its Relationship with Oral Bioaccessibility Using a Multi-Compartment In Vitro Gastrointestinal Model. 2020 SOT Virtual Meeting, virtual, April 16 - June 30, 2020.
Impact/Purpose:
Arsenic poses a “significant potential threat to human health” due to its high level of toxicity, worldwide prevalence. Understanding the factors that impact arsenic bioaccessibility and the effects oral ingestion of arsenic have in the gastrointestinal (GI) system can lend insight into risk of exposure and the potential for toxicity and negative health effects. This research investigates both physiochemical properties of the GI fluids and arsenic-contaminated matrices coupled with alterations of (and by) the gut microbiome providing insights on the important roles multiple factors play in the physiological solubility of arsenic in the gut.
Description:
The World Health Organization and the Agency for Toxic Substances and Disease Registry ranks arsenic high on the list of substances posing a “significant potential threat to human health” due to its high level of toxicity, worldwide prevalence, and exposure of millions of people around the world to elevated levels. Understanding the factors that impact arsenic bioaccessibility and the effects oral ingestion of arsenic have in the gastrointestinal (GI) system can lend insight into risk of exposure and the potential for toxicity and negative health effects. Factors such as physiochemical properties of the GI fluids and of metal-contaminated soils have been shown to impact the bioaccessibility of arsenic in contaminated soils. More recently, disturbances to the gut microbiome have been found after exposure to arsenic. Investigating both physiochemical properties of the GI fluids and arsenic-contaminated matrices coupled with alterations of (and by) the gut microbiome can showcase the important roles multiple factors play in the subsequent physiological solubility of arsenic in the gut. This research characterized the gut microbiome, before and after exposure to arsenic-contaminated soils using a multi-compartment simulated GI compartment (GIMS) inoculated with fecal or cecal bacteria. The percent bioaccessibility of arsenic at each phase of digestion (i.e. stomach, small intestine, and colon) after GIMS stabilization was also determined.
