Innovative Approaches to Assessing Thyroid Disruption: The 3D Human Thyroid Microtissue Model
Citation:
Deisenroth, C. Innovative Approaches to Assessing Thyroid Disruption: The 3D Human Thyroid Microtissue Model. Presented at LifeNet Health Webinar Series, Virtual Meeting, VA, May 09, 2024. https://doi.org/10.23645/epacomptox.25988032
Impact/Purpose:
Communicate the state of the science on thyroid new approach methodologies to the attendees of the LifeNet Health webinar series. Key topics include development of the 3D thyroid microtissue model, model performance, and standardization of the model for thyroid disruption testing.
Description:
In this LifeNet Health webinar, Dr. Deisenroth introduces an advanced human in vitro 3D thyroid microtissue model designed to evaluate thyroid hormone disruption, addressing current challenges with existing models. He will discuss the US EPA Endocrine Disruptor Screening Program’s (EDSP) approach to screen chemicals for potential thyroid-disrupting effects and the urgent need to advance new approach methods that protect human health while reducing animal testing. He will showcase how hormone production in the model mimics human endocrine biology and is inhibited following exposure to known reference chemicals that affect key targets within the thyroid gland. He will also explain the methodology behind establishing minimum donor qualification criteria and benchmark parameters for test method standardization, transferability, and validation. This approach balances performance standardization with the ability to predict a range of human responses.
URLs/Downloads:
DOI: Innovative Approaches to Assessing Thyroid Disruption: The 3D Human Thyroid Microtissue Model