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High-Throughput In Vitro–In Vivo Extrapolation for Predictive Toxicology
Citation:
Wetmore, B. High-Throughput In Vitro–In Vivo Extrapolation for Predictive Toxicology. SOT, Salt Lake City, UT, March 10 - 14, 2024. https://doi.org/10.23645/epacomptox.25400113
Impact/Purpose:
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Description:
These introductory remarks will provide historical context with an emphasis on regulatory prospects for high throughput toxicokinetic (HTTK) methods. HTTK methods were first applied to prioritize chemicals with respect to human risk in a 2010 Toxicological Sciences article. Since then, these methods have been reviewed and debated throughout the international scientific community, with heightened scrutiny by U.S. federal government scientific advisory panels and the U.S. National Academies of Science, Engineering, and Medicine. Meanwhile, public health regulatory agencies across the world have begun incorporating high throughput methods for in vitro-in vivo extrapolation (IVIVE) to determine toxicological points of departure from new approach methodologies (NAMs). This introduction will tee up topics to be discussed during the course, which are designed to facilitate greater understanding of these approaches, the tools that have been developed to facilitate their usage, and the opportunities and challenges that remain as stakeholders consider their application in regulatory decision-making. This abstract does not reflect EPA policy.
URLs/Downloads:
DOI: High-Throughput In Vitro–In Vivo Extrapolation for Predictive Toxicology
PRESENTATION.PDF (PDF, NA pp, 3894.179 KB, about PDF)