You are here:
Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS) v6.0
Citation:
LaLone, C. Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS) v6.0. U.S. Environmental Protection Agency, Washington, DC, 2021.
Impact/Purpose:
The SeqAPASS v6.0 tool allows users to compare protein similarity across species. This is important because chemicals act on protein targets. Therefore, by understanding how similar proteins are across species, the SeqAPASS tool can produce chemical susceptibility predictions across hundreds of species rapidly.
Description:
The US Environmental Protection Agency Sequence Alignment to Predict Across Species Susceptibility tool (SeqAPASS; https://seqapass.epa.gov/seqapass/) was developed to comparatively evaluate protein sequence and structural similarity across species as a means to extrapolate toxicity data/knowledge. SeqAPASS output provides a prediction of chemical susceptibility based on principles of evolutionary biology in understanding species relatedness at the molecular level. New to SeqAPASS Version 6 include the following: • A widget has been developed to rapidly connect SeqAPASS sequence-based predictions of chemical susceptibility to existing curated empirical toxicity data for terrestrial and aquatic species. The ECOTOXicology Knowledgebase (https://cfpub.epa.gov/ecotox/) is a publicly available resource for single chemical environmental toxicity data on aquatic life, terrestrial plants and wildlife. Therefore, an ECOTOX Widget is now available within SeqAPASS for users to readily select species from SeqAPASS output on the Level 1 results page and chemical(s) of interest to pass to the ECOTOX Knowledgebase Explore feature and identify relevant toxicity data.