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Chemical absorption in the layers of human skin (NCSU 2023)
Citation:
Stevens, J., A. Prockter, H. Fisher, H. Tran, AND M. Evans. Chemical absorption in the layers of human skin (NCSU 2023). NCSU, Raleigh, NC, November 18 - 19, 2023. https://doi.org/10.23645/epacomptox.24970104
Impact/Purpose:
N/A
Description:
Whether from environmental and occupational hazards or from topical pharmaceuticals, the human skin comes into contact with various chemicals every day. In vivo experiments not only require large investments of both time and money, but in vivo experiments can also be unethical due to the need to intentionally or incidentally expose humans or animals to toxic chemicals. Comparatively, in vitro experiments offer ethical and financial advantages when combined with the opportunity to selectively choose chemicals for experimentation. With experimentation being so infeasible, many scientists have chosen to make their in vitro data available publicly. Using publicly available data, a detailed database was created to be used in connection with mathematical modeling to predict diffusion, permeability, and partition coefficients. A robust set of features was compiled for 73 chemicals in addition to coefficients for permeability, partition, and diffusion. This resulting database is tailored to be easily used in various coding languages and ultimately with machine learning techniques.
URLs/Downloads:
DOI: Chemical absorption in the layers of human skin (NCSU 2023)
PRESENTATION.PDF (PDF, NA pp, 2738.304 KB, about PDF)