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Navigating the Complex Landscape of Human Biomonitoring Data for Chemistry and Exposure Assessment
Citation:
Stanfield, Z. AND R. Sayre. Navigating the Complex Landscape of Human Biomonitoring Data for Chemistry and Exposure Assessment. SETAC, Louisville, KY, November 12 - 16, 2023.
Impact/Purpose:
N/A
Description:
Biomonitoring data can provide important information about exposure to chemicals in the environment aggregated across all pathways. Depending on the study design, biomonitoring surveys can elucidate population-specific risks, exposure patterns over time, and relationships between chemicals and observed health effects. However, there is a complexity inherent to these data due to population variability, analytical methods, and sampling choices. Any approaches or tools built around biomonitoring data need to sufficiently understand and manage these contributors to uncertainty. In addition, leveraging other forms of data (e.g., known exposure pathways for environmental chemicals, metabolites and biotransformation processes of xenobiotics, and cell-based bioassay measurements) alongside biomonitoring studies offers opportunity for greater application of biomonitoring data in exposure science. There is an ever-evolving body of methods and tools used to infer chemical exposures from these data, particularly to estimate risks from real-world scenarios involving cumulative exposures and exposure to mixtures. This session will present the latest advancements in conceptualizing statistical methods for biomonitoring and uses for existing biomonitoring data (such as the National Health and Nutrition Examination Survey (NHANES)), including novel tools for exposure and risk assessment. We encourage presentations addressing quantification of uncertainty and variability as it relates to biomonitoring data characteristics, novel uses of biomonitoring data, population-specific risk assessments, trends across biomonitoring studies over time, and incorporation of multiple data sources to provide new insights into human exposure. This abstract does not necessarily reflect the view or policies of the U.S. Environmental Protection Agency.