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Introducing the Public-Facing ChemExpo Knowledgebase Web Application Supporting Delivery of Chemical Use and Consumer Product Data to Inform Exposure Assessment
Citation:
Handa, S., K. Baron-Furuyama, K. Phillips, T. Wall, M. Horton, C. Lutz, A. Larger, K. Isaacs, AND C. Elonen. Introducing the Public-Facing ChemExpo Knowledgebase Web Application Supporting Delivery of Chemical Use and Consumer Product Data to Inform Exposure Assessment. ISES, Chicago, IL, August 27 - 31, 2023. https://doi.org/10.23645/epacomptox.24001557
Impact/Purpose:
ChemExpoDB is an integrated family of exposure databases (including CPDat), linking data across multiple different exposure data streams. The software application Factotum was developed to assist with managing, curating, and ensuring the quality of the data within ChemExpoDB. Factotum has facilitated the rapid collection and curation of chemical use data to improve the volume, quality and accessibility of exposure related data for decision making by EPA Stakeholders. To date, Factotum has been used to upload more than 560,000 publicly available data documents, with 4.0 million chemical-specific records extracted from these documents. Presently, 2.7 million of these raw chemical records have been curated to harmonized substance identifiers (DTXSIDs). Factotum will support a new public-facing data search and visualization tool, ChemExpo Explorer, that will display detailed curated data, including additional document metadata and raw reported information. This application will allow for interactive exploration of curated Factotum data by chemical, function, and consumer product category. This application will increase the timeliness, transparency and accessibility of high quality exposure data to scientists, regulators and the general public for use in exposure assessments.
Description:
To support chemical decision-making, EPA's Office of Research and Development (ORD) must identify and characterize exposure pathways; How a chemical is used (e.g., in a consumer, occupational, or industrial context) is critical to determining exposure pathways. The ORD data management and curation application, Factotum, facilitates the rapid collection and distribution of high-quality chemical use and exposure-related data from publicly available documents to inform chemical exposure and risk assessments. Factotum has been used to manage and curate data from over 560,000 documents, representing 4 million individual chemical records and 36,000 unique chemical substances. To surface data curated within Factotum, ORD has developed a new publicly available data search and visualization tool, called Chemical Exposure Knowledgebase (ChemExpo). The initial release of ChemExpo will allow for search, exploration, and download of chemical use data, including specific chemical substances, chemical composition of consumer products, functional role of chemicals within products and processes, and presence of chemicals on reported specific or general use lists. ChemExpo contains more detailed exposure data than are currently available via EPA’s CompTox Chemicals Dashboard, including additional document metadata, product-level chemical ingredient information, and product category, function category, and chemical summaries. Application functionality and data terminology are well-documented via a comprehensive user guide, including use cases to aid user exploration. By making this application publicly available, EPA ORD aims to increase transparency and accessibility of exposure relevant data to researchers, regulators, and consumers to support exposure assessments and other risk-based chemical evaluations. This abstract does not necessarily reflect U.S. EPA policy.
URLs/Downloads:
DOI: Introducing the Public-Facing ChemExpo Knowledgebase Web Application Supporting Delivery of Chemical Use and Consumer Product Data to Inform Exposure Assessment
POSTER.PDF (PDF, NA pp, 1194.738 KB, about PDF)