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Evaluating the bioactivity of the ubiquitous tire preservative 6PPD and its quinone transformation product
Citation:
Villeneuve, D., T. Shafer, S. Padilla, J. Harrill, AND M. Jankowski. Evaluating the bioactivity of the ubiquitous tire preservative 6PPD and its quinone transformation product. National EPA Tribal Science Council, Fall 2022 Face-to-Face Meeting, Research Triangle Park, NC, December 06 - 08, 2022. https://doi.org/10.23645/epacomptox.21714164
Impact/Purpose:
An environmental transformation product of the ubiquitous tire-rubber antioxidant, N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD), has been identified as the likely causative agent causing urban run-off associated pre-spawn mortality in migrating coho salmon (Oncorhynchus kisutch) in the Pacific Northwest (Tian et al. 2021). This compound, 6PPD-quinone (6PPD-q) was shown to be highly toxic to both coho salmon and steelhead (Oncorhynchus mykiss), but the potential sub-lethal toxicity of 6PPD-q and the mechanistic basis for large differences in sensitivity among species has not been characterized. Given the impacts that 6PPD-q is having on Pacific Northwest Salmonid populations and associated impacts on other species in associated Ecosystems like Southern resident killer whales (Orcinus orca) in Puget Sound, EPA Region 10 had an urgent interest in collecting additional hazard data for 6PPD-q and directly contacted ORD-CCTE about employing its tiered screening assays for that purpose. Subsequently, many tribes have expressed interest in more information concerning the hazards of 6PPD-q This presentations reports on results of several screening-level characterization of the hazard(s) associated with 6PPD-q. The results increase the understanding of what model systems are and are not sensitive to 6PPD-q and provided insights into an appropriate screening assay for use in the evaluation of potential replacement chemicals as well as urban run-off samples.
Description:
Presentation to the National EPA Tribal Science Council, Fall 2022 Face-to-Face Meeting December 2022
URLs/Downloads:
DOI: Evaluating the bioactivity of the ubiquitous tire preservative 6PPD and its quinone transformation product
VILLENEUVE_TSC_6PPD-Q 12-07-2022_V3.PDF (PDF, NA pp, 4290.907 KB, about PDF)