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A Scoping Assessment of Implemented Toxicokinetic Models of Per- and Polyfluoro-Alkyl Substances, with a Focus on One-Compartment Models
Citation:
East, A., D. Dawson, S. Brady, D. Vallero, AND R. Tornero-Velez. A Scoping Assessment of Implemented Toxicokinetic Models of Per- and Polyfluoro-Alkyl Substances, with a Focus on One-Compartment Models. Toxics. MDPI, Basel, Switzerland, 11(2):163, (2023). https://doi.org/10.3390/toxics11020163
Impact/Purpose:
Purpose: Physiologically-based toxicokinetic (PBTK) modeling often provide target tissue dosimetry as input to chemical risk assessments. However, for most PFAS compounds there is relative lack of reliable experimental toxicokinetic data and interspecies uncertainties, as well as toxicokinetic variability in population attributes, e.g., variations by sex and age. Thus, the parameterization of mechanistic models of PFAS toxicokinetics using PBTK remains a challenge. Conversely, parsimonious models (i.e., one-compartment) are commonly used and reported in the literature for both “data-rich” and well-studied PFAS (especially, PFOA and PFOS), but also for many data-poor scenarios. To identify potentially useful PBTK approaches for PFAS, we used a systematic evidence-mapping approach we conducted a scoping assessment to systematically map the current landscape for PFAS toxicokinetic models, categorizing different trends and similarities according to model type, specific PFAS compound, and use scenario. Impact: This scoping assessment identified influential models, generic one compartment model structures, and the breadth of existing publications which apply TK models for PFAS. This paper provides a resource for regulators, non-modelers, modelers, and risk assessor on toxicokinetic models applied to PFAS. More generally, this paper advances evidence mapping methodology through application of bibliometric analysis (e.g., co-citation analysis).
Description:
Toxicokinetic (TK) models have been used for decades to estimate concentrations of per-and polyfluoroalkyl substances (PFAS) in serum. However, model complexity has varied across studies depending on the application and the state of the science. This scoping effort seeks to systematically map the current landscape of PFAS TK models by categorizing different trends and similarities across model type, PFAS, and use scenario. A literature review using Web of Science and SWIFT-Review was used to identify TK models used for PFAS. The assessment covered publications from 2005–2020. PFOA, the PFAS for which most models were designed, was included in 69 of the 92 papers, followed by PFOS with 60, PFHxS with 22, and PFNA with 15. Only 4 of the 92 papers did not include analysis of PFOA, PFOS, PFNA, or PFHxS. Within the corpus, 50 papers contained a one-compartment model, 17 two-compartment models were found, and 33 used physiologically based pharmacokinetic (PBTK) models. The scoping assessment suggests that scientific interest has centered around two chemicals—PFOA and PFOS—and most analyses use one-compartment models in human exposure scenarios.
URLs/Downloads:
DOI: A Scoping Assessment of Implemented Toxicokinetic Models of Per- and Polyfluoro-Alkyl Substances, with a Focus on One-Compartment Models
https://pubmed.ncbi.nlm.nih.gov/36851038/