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Application of DNT NAMs data in Regulatory Scenarios
Citation:
Shafer, T. Application of DNT NAMs data in Regulatory Scenarios. American Society for Cellular and Computational Toxicology, RTP, NC, October 19 - 21, 2022. https://doi.org/10.23645/epacomptox.21807096
Impact/Purpose:
Presentation to the 11th annual meeting of the American Society for Cellular and Computational Toxicology (ASCCT) October 2022. This presentation describes several case-studies on the use of DNT NAMs in decision-making by the Agency.
Description:
Assessment of Developmental Neurotoxicity (DNT) using animal-based Guideline studies is expensive, time consuming, and does not always yield actionable data. Further, DNT assessment is not required under TSCA and the Guideline DNT study is a triggered study under FIFRA. Consequently, few of the tens of thousands of chemicals to which humans may be exposed have been evaluated for DNT hazard. To address this issue, New Approach Methodologies (NAMs) are being developed that can help provide data for risk decisions under FIFRA and TSCA. As these methods become more widely utilized, they can also provide information for other types of environmental decision-making as well.
URLs/Downloads:
DOI: Application of DNT NAMs data in Regulatory Scenarios
SHAFER ASCCTV3.PDF (PDF, NA pp, 3560.916 KB, about PDF)