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EPA’s Systematic Empirical Evaluation of Models (SEEM) Framework
Citation:
Wambaugh, J., C. Ring, AND K. Isaacs. EPA’s Systematic Empirical Evaluation of Models (SEEM) Framework. Quantitative Structure-Use Relationship (QSUR) Model Summit, Raleigh, NC, November 02 - 04, 2022. https://doi.org/10.23645/epacomptox.21430464
Impact/Purpose:
This is a presentation to the Quantitative Structure-Use Relationship (QSUR) Model Summit scheduled for November 2-4 in Raleigh, NC. The presentation is entitled: “EPA’s Systematic Empirical Evaluation of Models (SEEM) Framework” and will be presented in a session on “Current State-of-the-Science use of QSURs to support exposure and risk estimation.”
Description:
The Systematic Empirical Evaluation of Models (SEEM) is a probabilistic, consensus prediction using multiple HTE models and other predictors . Various High-Throughput Exposure (HTE) models provide the predictions for different aspects of exposure. Monitoring data provides our “reference” exposures for evaluating the mdels. Quantiative structure-use relationship (QSUR) “pathway models” provide exposure model “domain of applicability” and allow us to know which model to use and when. Of 687,359 chemicals evaluated, 30% have less than a 50% probability for exposure via any of the four pathways and are considered outside the domain of applicability
URLs/Downloads:
DOI: EPA’s Systematic Empirical Evaluation of Models (SEEM) Framework
QSUR2022-WAMBAUGH-SEEM3-110222-DRAFT3.PDF (PDF, NA pp, 3338.661 KB, about PDF)