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ToxRefDB version 2.1
Citation:
Feshuk, M., L. Kolaczkowski, S. Addanki, K. Friedman, AND S. Watford. ToxRefDB version 2.1. U.S. Environmental Protection Agency, Washington, DC, 2022. https://doi.org/10.23645/epacomptox.6062545
Impact/Purpose:
ToxRefDB contains in vivo study data from over 5900 guideline or guideline-like studies for over 1100 chemicals. This is largely comprised of curated animal study data from repeat dose studies conducted according to Health Effects Series 870 guidelines, and many of these studies (over 3,000 of them) come from registrant-submitted toxicity studies known as data evaluation records (DERs) from the U.S. EPA’s Office of Pesticide Programs (OPP). By employing a controlled vocabulary for enhanced data quality, ToxRefDB serves as a resource for study design, quantitative dose response, and endpoint testing status information given guideline specifications. The database can aid in the validation of in vitro high throughput screening of chemicals and serve as a resource for retrospective and predictive toxicology applications.
Description:
Release of the next version of ToxRefDB, relying on a reproducible and supported ETL process. Actual planned completion date: FY22 Q4
