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Daphnia magna and Ceriodaphnia dubia Have Similar Sensitivity in Standard Acute and Chronic Toxicity Tests
Citation:
Connors, K., J. Brill, T. Norberg-King, M. Barron, G. Carr, AND S. Belanger. Daphnia magna and Ceriodaphnia dubia Have Similar Sensitivity in Standard Acute and Chronic Toxicity Tests. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 41(1):134-147, (2022). https://doi.org/10.1002/etc.5249
Impact/Purpose:
The paper was a data extraction evaluation that compares the sensitivity of two standard aquatic invertebrate species used to test the toxicity of environmental samples and chemicals. The impact of the work is that it is a definitive assessment of the sensitivity of these two species commonly used in environmental hazard assessment. The findings of the research show similar sensitivity of the species in toxicity tests, suggesting that the data for each species may be used interchangeably. This could reduce future animal testing and result in more informed hazard assessment by using the data of one of these species as a surrogate for the other species.
Description:
The cladocerans Daphnia magna and Ceriodaphnia dubia have been used for decades to assess the hazards of chemicals and effluents, but toxicity data for these species have traditionally been treated separately. Numerous standard acute and chronic test guidelines have been developed for both species. In the present study, data were compiled and curated for acute survival (48 h) and growth and reproduction tests with D. magna (21 days chronic) and C. dubia (7 days chronic) toxicity assays. Orthogonal regressions were developed to statistically compare the acute and chronic sensitivity of D. magna and C. dubia across a diversity of chemicals and modes of action. Acute orthogonal regressions between D. magna and D. pulex, a widely accepted surrogate species, were used to set a data-driven benchmark for what would constitute a suitable D. magna surrogate. The results indicate that there is insufficient evidence to suggest a difference in acute or chronic sensitivity of D. magna and C. dubia in standard toxicity tests. Further, the variability in the acute D. magna and C. dubia regressions were of the same magnitude as that in D. magna and D. pulex regressions. Slope and y-intercept values were also comparable. The absence of significant differences in toxicity values suggests similar species sensitivity in standard tests across a range of chemical classes and modes of action.
URLs/Downloads:
DOI: Daphnia magna and Ceriodaphnia dubia Have Similar Sensitivity in Standard Acute and Chronic Toxicity Tests
https://pubmed.ncbi.nlm.nih.gov/34918372/