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Species Sensitivities: Evaluating Conservation Using the SeqAPASS Tool
Citation:
LaLone, C. Species Sensitivities: Evaluating Conservation Using the SeqAPASS Tool. Euromarine Workshop MODEL-EDC: Threats and tools for Endocrine-Disrupting pollutants in Marine organisms, Duluth, MN, November 22 - 23, 2021. https://doi.org/10.23645/epacomptox.18712061
Impact/Purpose:
Presentation to the Euromarine Workshop MODEL-EDC: Threats and tools for Endocrine-Disrupting pollutants in Marine organisms November 2021. Endocrine disrupting chemicals (EDCs) continue to be an issue of concern in aquatic environments, but EDC effects have been less well studied in marine than freshwater systems, a topic addressed from a practical perspective at this workshop. My talk will describe the SeqAPASS tool and how it is used to evaluate protein conservation to provide evidence for cross species extrapolation to help assess ecological risks of EDCs.
Description:
Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS), is a fast, online screening tool that allows researchers and regulators to extrapolate toxicity information across species. For some species, such as humans, mice, rats, and zebrafish, the EPA has a large amount of data regarding their toxicological susceptibility to various chemicals. However, the toxicity data for numerous other plants and animals is very limited. SeqAPASS extrapolates from these data rich model organisms to thousands of other non-target species to evaluate their specific potential chemical susceptibility. This abstract does not necessarily reflect U.S. EPA policy.
URLs/Downloads:
DOI: Species Sensitivities: Evaluating Conservation Using the SeqAPASS Tool
SEQAPASS_MARINE_SPECIES.PDF (PDF, NA pp, 4833.697 KB, about PDF)