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New Approach Methodologies for Exposure: Advancing Chemical Risk Assessment
Citation:
Wambaugh, J. AND A. Zidek. New Approach Methodologies for Exposure: Advancing Chemical Risk Assessment. Society of Toxicology Virtual 2021 Annual Meeting, Virtual, NC, March 12 - 26, 2021. https://doi.org/10.23645/epacomptox.14498004
Impact/Purpose:
Introductory presentation to the Society of Toxicology 2021 Workshop March 2021 titled 'New Approach Methodologies for Exposure: Advancing Chemical Risk Assessment'.
Description:
This SOT workshop will review new approach methodologies (NAMs) for exposure science that have been developed to address the thousands of chemicals in commerce and the environment with little or no data. Public health chemical risk is the product of both inherent chemical toxicity and the potential for human exposure. The tools to characterize both toxicity and exposure have evolved significantly in the past decade. NAMs for exposure science are being developed to enable risk assessors to more rapidly address public health challenges and chemical regulation. These chemicals include those present in the home (such as flame retardants, plasticizers, fragrances),occupational settings (such as pesticides, solvents, cleaners), and the environment (such as persistent organic pollutants and “down the drain” pharmaceuticals and consumer product ingredients). NAMs for exposure science include (1) new methods that can be broadly applied for biomonitoring and biostatistics, (2) the application of machine learning to data-poor situations, (3) high-throughput exposure models for making predictions from limited chemical and scenario descriptors, (4) high-throughput toxicokinetic data and models enabling in vitro to in vivo extrapolation (IVIVE) of high-throughput toxicity data, and (5) chemical risk prioritization strategies that can be broadly applied across large numbers of chemicals. This Workshop will review new technological developments advancing exposure science as well as provide case studies of how NAMs are now being used. All the NAMs presented can inform assessment of the chemical effects on public health. In this session, each speaker will:Present a NAM for exposure, with an emphasis on the most recent developments; describe the key challenges in understanding that NAM; describe publicly available data and tools that are available to toxicologists; demonstrate application of the exposure NAM to toxicology and chemical risk assessment; clearly identify the chemical “domain of applicability” and any underrepresented chemical classes; identify obstacles to regulatory acceptance of the exposure NAM. The Workshop will conclude with a moderated panel discussion where speakers will address audience questions on how to apply the presented methods in chemical risk assessment. The views expressed are those of the author and do not necessarily reflect the views or policies of the US EPA.
URLs/Downloads:
DOI: New Approach Methodologies for Exposure: Advancing Chemical Risk Assessment
WAMBAUGH_SOT2021-NAMSFOREXPOSURE.PDF (PDF, NA pp, 1055.946 KB, about PDF)