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SeqAPASS demo
Citation:
LaLone, C. SeqAPASS demo. EPA Board of Scientific Councilors (BOSC) Virtual Meeting, Duluth, MN, February 02 - 05, 2021. https://doi.org/10.23645/epacomptox.13626383
Impact/Purpose:
This presentation will be a demo of the Sequence Alignment to Predict Across Species Susceptibility (version 5.0) tool. Demonstrations will focus on the new and enhanced features in data visualization, synthesis, and interpretation.
Description:
The US Environmental Protection Agency Sequence Alignment to Predict Across Species Susceptibility tool (SeqAPASS; https://seqapass.epa.gov/seqapass/) was developed to comparatively evaluate protein sequence and structural similarity across species as a means to extrapolate toxicity data/knowledge. SeqAPASS output provides a prediction of chemical susceptibility based on principles of evolutionary biology in understanding species relatedness at the molecular level. New to SeqAPASS Version 5 include the following: • SeqAPASS Level 3 individual amino acid comparisons now have a customizable heat map visualization for rapid interpretation of the data and utility for publication and presentation quality graphics. • In order to synthesize SeqAPASS results (i.e., data tables and visualizations) across all Levels (1, 2, and 3) of the SeqAPASS evaluation, a customizable Decision Summary Report has been created. Users can now push SeqAPASS results to a final downloadable (.pdf) summary report. These features will be highlighted during a live demonstration.
