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Growing Up and Leaving Home: Emerging from the Teenage Years in 21st Century Computational Toxicology
Citation:
Thomas, R. Growing Up and Leaving Home: Emerging from the Teenage Years in 21st Century Computational Toxicology. North Carolina Society of Toxicology annual meeting, RTP, NC, September 17 - 23, 2020. https://doi.org/10.23645/epacomptox.13356200
Impact/Purpose:
Keynote presentation given to the NC Society of Toxicology annual meeting September 2020
Description:
This presentation will give an overview of the beginnings of computational toxicology and showcase the exciting work being done today. The application of computational modeling to toxicological endpoints began with development of QSARs in 1970s. Also in the early 1970s, the first physiologically-based pharmacokinetic (PBPK) models were developed. In the 1980s, significant growth occurred in computer modeling in QSAR and PBPK modeling. In the 1990s, development of physiologically-based pharmacodynamic (PBPD) models for AChE inhibition and cell death/proliferation/mutation. In the late 1990s, use of the term ‘computational toxicology’ appeared in the literature. A strategic plan for Computational Toxicology research at EPA was released in 2003. In 2019 and 2020, an EPA Advanced Directive memo and work plan continues to spur development and shift towards Computational Toxicology. Some of the goals are to reduce requests for, and funding of, mammalian studies by 30% by 2025; and to eliminate all mammalian study requests and funding by 2035.
URLs/Downloads:
DOI: Growing Up and Leaving Home: Emerging from the Teenage Years in 21st Century Computational Toxicology
THOMAS_COMPTOX GROWING UP_NCSOT_SEPT_2020_V1.PDF (PDF, NA pp, 8208.912 KB, about PDF)