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AOP Development
Citation:
LaLone, C. AOP Development. University of Minnesota, PUBH 8160, Advance Toxicology, Fall 2020 Lecture, Duluth, MN, September 22, 2020. https://doi.org/10.23645/epacomptox.12962681
Impact/Purpose:
This course will focus on the development and application of Adverse Outcome Pathways (AOPs)as a framework for integrating existing knowledge to construct a biological pathway that links molecular initiating events induced by chemicals and classes of chemicals with specific adverse outcomes, such as cancer, neurotoxicity, and reproductive and developmental toxicity. This course requires students to read and critically analyze and interpret current primary literature in toxicology, and integrate the information to develop and analyze adverse outcome pathways. As a component of this course, this lecture will focus on tools that are currently available to aid in the development of AOPs
Description:
The lecture will focus on the following; Review of key aspects of weight of evidence assembly for AOPs Strategies and tools to aid AOP development • AOP-Wiki • ECOTOX Knowledgebase • SeqAPASS Case examples
