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Advancing translational applications of human organotypic thyroid assays (Die Akademie Fresenius Conference)
Citation:
Deisenroth, C. Advancing translational applications of human organotypic thyroid assays (Die Akademie Fresenius Conference). Die Akademie Fresenius Conference - Assessment of Thyroid Disrupting Chemicals, Virtual conference, N/A, GERMANY, February 01 - 02, 2023. https://doi.org/10.23645/epacomptox.22751114
Impact/Purpose:
This invited presentation will take place at the Die Akademie Fresenius online conference February 2023 on the Assessment of Thyroid Disrupting Chemicals covering the latest developments in thyroid-related NAMs, regulatory issues and other EU-wide projects. This presentation provides updates on efforts within EPA-ORD to advance translational applications of human organotypic thyroid assays as defined in the Chemical Safety for Sustainability national research program.
Description:
There is significant regulatory need in the Endocrine Disruptor Screening Program (EDSP) to identify and evaluate chemicals that may disrupt the thyroid endocrine system. The New Approach Methods (NAMs) Work Plan seeks to support refinement and replacement of animal testing by addressing scientific challenges, inclusive of those in the EDSP, that fill information gaps in chemical safety research. This presentation provides updates in advancing translational applications of human organotypic thyroid assays. Highlights include development of a human thyroid organotypic culture model to address data gaps in screening and prioritization of thyroid disrupting chemicals, establishing confidence with an inter-laboratory prevalidation study of the human thyroid microtissue assay, and orthogonal screening of prioritized chemicals in human thyroid microtissues for functional and mechanistic relevance.
URLs/Downloads:
DOI: Advancing translational applications of human organotypic thyroid assays (Die Akademie Fresenius Conference)
2023FEB02_EPA_DEISENROTH_AKADAMIE FRESNENIUS CONF_V10_FINAL.PDF (PDF, NA pp, 3707.924 KB, about PDF)