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Advancing Translational Applications of Human Organotypic Thyroid Assays (CompTox CofP)
Citation:
Deisenroth, C. Advancing Translational Applications of Human Organotypic Thyroid Assays (CompTox CofP). Computational Toxicology and Exposure Communities of Practice, Research Triangle Park, NC, February 23, 2023. https://doi.org/10.23645/epacomptox.22770314
Impact/Purpose:
This is an informational presentation on new approach methods for evaluating thyroid hormone disrution conducted via the Computational Toxicology and Exposure Communities of Practice seminar series on February 23rd, 2023.
Description:
There is significant regulatory need to identify and evaluate chemicals that may disrupt the thyroid endocrine system. Thyroid new approach methods (NAMs) are being developed and applied to increase data coverage across the ToxCast/Tox21 chemical inventories using a tiered testing strategy. Interpreting the biological effect of chemicals identified in thyroid high-throughput screening assays remains a considerable challenge. Continued efforts to build new in vitro and in silico approach methods are necessary for evaluating the potential health impacts of thyroid-related toxicity. Ongoing work will address efforts to increase the confidence in applying human organotypic thyroid screening assays to evaluate the mechanistic and biological relevance of chemical effects on thyroid hormone function. The impact of these efforts may enable more robust assessments of thyroid disrupting chemicals using a human-based NAM approach.
URLs/Downloads:
DOI: Advancing Translational Applications of Human Organotypic Thyroid Assays (CompTox CofP)
2023FEB23_DEISENROTH_EPA COP SEMINAR_V1.PDF (PDF, NA pp, 5801.032 KB, about PDF)