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Translatability of Cell Based and In Silico Models of Developmental Toxicity
Citation:
Knudsen, T. Translatability of Cell Based and In Silico Models of Developmental Toxicity. Presented at Pharmaceutical and BioScience Society (PBSS), Bay Area, NA, Virtual, November 03 - 04, 2021. https://doi.org/10.23645/epacomptox.17201753
Impact/Purpose:
This is an invited lecture in a CE course on 'Reproductive and Juvenile Toxicity Workshop' to the Pharmaceutical and BioScience Society (PBSS)
Description:
High throughput screening (HTS) assays with pluripotent stem cells (PSCs) offer a promising alternative to pregnant animals for assessing developmental toxicity. Their unique properties help them to be excellent models of the developing embryo during stages when the basic body plan is ‘decoded’ from the genomic blueprint. Many studies have shown predictive value for developmental toxicity; however, descaling the human embryo to hPSCs can be blind to systems reconstitution. Engineered microsystems and integrative computational models that recapitulate the full complementation of an embryo will be needed for translatability.
